Aim and Background: The present study was conducted with the aim of comparing the effectiveness of commitment-based therapy on Anhedonia, Meaning in Life, Emotional Empathy, Child Parent Relationship and Quality of Life in Children, in Mothers of Children With Cancer.

Methods and Materials: The present study was a semi-experimental design of pre-test and post-test with a one-month follow-up test with a control group. The sample consisted of 36 mothers of children with cancer who visited Omid Shahr Hospital in Isfahan during the second 6 months of 1402. The subjects were selected by random sampling and randomly assigned to two experimental and control groups. the lack of hedonism questionnaire of Snit et al. (1995); Questionnaire of meaning in life Stegar et al. (2006); Emotional Empathy Questionnaire of Mehrabian and Epstein (1972); Pianta's Parent-Child Relationship Scale (1994); Children's quality of life scale was Varney, Sid, Curtin (2003). Also, mothers received 8 sessions of 90-minute commitment and acceptance therapy based on Westrup and Wright (2017) and Gilbert's compassion therapy (2009) were used to collect data and the collected data were analyzed with the help of Spss-23 software.

Findings: The findings showed that in the experimental group, the difference between the average scores of the pre-test, post-test and follow-up scores of lack of enjoyment of meaning in life, emotional empathy, parent-child relationship and child's quality of life is significant (P<0.01), but in The control group is not significant.