The purpose of this study was to determine the effectiveness of MBSR Stress Reduction (MBRI) on reducing the anxiety, depression and marital satisfaction of infertile women. The present study was semi-experimental with two groups of experimental and control in two stages: pre-test and post-test. The statistical population of this study was 250 women infertility in Isfahan who referred to Mashhahak Infertility Center in Isfahan during the first 6 months of 1396, of whom 40 were selected by purposeful sampling and divided into two groups Control (20 people) and experimental (20 people). The experimental group received 8 sessions for one and a half hours under the psychotherapy package based on Johnson's stress reduction (2011) based on the theory of Zaban (1990), while the control group did not receive any training. In the pre-test and post-test, both groups filled out 14 questions about marital satisfaction (1388) and the 14 questions of anxiety and depression questionnaire from 21 questionnaires of depression, anxiety, stress, DASS, Leviibond and Laweibond (1995), aggregated information The data was analyzed using spss software version 21 in descriptive and inferential sections. Data analysis with covariance analysis showed that the reduction of stress-based mind-awareness training in group method in reducing anxiety, depression and increasing marital satisfaction of infertile women had a significant effect (p <0.05).