The purpose of this research was the effectiveness of compassion therapy and Logotherapy in reducing depression and increasing the adjustment of families of drug addicts in Isfahan city. The method of the present research was quasi-experimental type of pre-test-post-test with a control group. The statistical population of this research includes all the spouses of people suffering from addiction who visited the "Baresh Mehr" addiction treatment center in Isfahan city in 1401-1402. The sample members of this research were 45 people who were randomly assigned to three experimental groups of compassion therapy (15 people), experimental group of Logotherapy (15 people) and control (15 people). The independent variables were compassion therapy based on Gilbert's treatment plan (8 sessions) and Logotherapy based on Frankel's treatment plan (10 sessions), which were performed in the experimental groups and not in the control group. These protocols were organized and compiled by the researcher of the article in 1400. The questionnaires used by the researcher in this research were Beck Depression Questionnaire and Marital Adjustment Questionnaire (DAS). Analysis of covariance statistical method was used to evaluate the results using SPSS27 software. Conclusion: The results showed that compassion therapy training (P<0.001) and Logotherapy (P<0.05) had a significant effect on reducing depression and increasing adaptation.