The present study aimed to compare the effectiveness of couples therapy based on choice theory and life skills training on conflict resolution, reducing divorce tendency and increasing the resilience of couples affected by infidelity. This research was applied in terms of purpose and semi-experimental method which was conducted with pretest-posttest design with control group. . The statistical population of the present study included all couples affected by infidelity who referred to counseling centers in Hamadan in 2021 and the sample consisted of 48 people who were randomly assigned to two experimental and control groups (each group 8 couples). Data were collected from three questionnaires, conflict resolution styles (Rahim, 1983), and decreased divorce desire (Rozlet, Johnson & Morrow, 1986). And resilience (Carner and Davidson, 2003) was used to collect data, and intervention sessions were conducted based on choice theory based couple therapy (Glasser, 1999) and Chris Life Skills Training Program (1998, quoted by Yousefi, 2016). Multivariate analysis of variance (MANOVA) and SPSS software were used to analyze the data and investigate research hypotheses. The findings of the study showed that couples therapy based on choice theory and life skills training had a positive effect on conflict resolution, reduction of divorce tendency and increasing resilience in couples affected by infidelity and these programs can be used as a useful intervention in conflict resolution, reducing the tendency to divorce and increasing resilience.