The present study aimed to model the structural relationship between media literacy and resilience mediated by cognitive emotion regulation in high school students in Qom. This research is applied in terms of its purpose and is of the structural equation modeling type in terms of its descriptive-correlational method. The statistical population of this study consisted of male and female students in Qom province who were studying in secondary schools in the academic year 2021-2022. The sample group consisted of 700 people (350 girls and 350 boys) who were selected using the cluster sampling method; Thus, from among the 4 educational districts of Qom province, 8 schools (4 for girls and 4 for boys) were randomly selected, and 88 students from each school were included in the study. In this study, questionnaire tools (Toman Media Literacy Questionnaire, 1995, Garnevsky et al.'s Cognitive Emotion Regulation Questionnaire, 2001 and Connor-Davidson's Resilience Questionnaire (2003) were used to collect data related to the variables. All statistical analyses were performed at the 0.05 error level using SmartPLS 3.2.8 software. The findings indicate a positive and significant direct effect of media literacy on resilience. On the other hand, the effect of media literacy on resilience is also positive and significant indirectly and mediated by cognitive emotion regulation. Therefore, it is possible to benefit from promoting media literacy and cognitive emotion regulation in a consistent manner by planning correctly to increase students' resilience.