The present study was conducted with the aim of predicting the quality of life based on the perception of suffering in irritable bowel syndrome patients and using a descriptive correlational method. The statistical population of the study was made up of patients suffering from irritable bowel syndrome in Isfahan, who were selected using the table of Karjesi and Morgan (1970) by available sampling method, 140 people. Patrick and Drasman (1998) Quality of Life Questionnaire and Scholz et al.'s (2010) Experience and Perception Scale were used to collect information. The results showed that among the variables studied in the regression, the best predictor of quality of life was existential/spiritual suffering in the first step and physical suffering in the second step. Based on the results of step-by-step regression analysis, the relationship between existential/spiritual suffering and physical suffering with quality of life was significant. Based on this, in the first step, the coefficient of existential/spiritual suffering explains 13.8% of the variance of quality of life, and in the second step, the coefficients of existential/spiritual suffering and physical suffering explain 21.5% of the variance of quality of life. Also, the beta coefficient decreases the quality of life by 0.313 units per one unit increase in existential/spiritual suffering, and the beta coefficient decreases the quality of life by 0.283 units per one unit increase in physical suffering.